Copper Status in Alzheimer's Disease and Other Neurodegenerative Disorders: Genetics, Mechanisms, Neurophysiology, and Therapies

نویسندگان

  • Rosanna Squitti
  • D. Larry Sparks
  • Tjaard U. Hoogenraad
  • George J. Brewer
چکیده

1Department of Neurology, “Campus Biomedico” University, 00128 Rome, Italy 2Department of Neuroscience, AFaR-Fatebenefratelli Hospital, 00186 Rome, Italy 3Roberts Laboratory for Neurodegenerative Disease Research, Banner Sun Health Research Institute, Sun City, AZ 85351, USA 4Department of Neurology, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands 5Department of Human Genetics, University of Michigan, Ann Arbor MI 48109, USA 6Department of Internal Medicine, University of Michigan, Ann Arbor MI 48109, USA 7Adeona Pharmaceuticals, Ann Arbor, MI 48103, USA

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The role of genetics in alzheimer’s disease

Alzheimer's disease is a progressive neurological disorder that causes the brain to shrink (atrophy) and brain cells die. Alzheimer's disease is the most common cause of dementia and causes a decrease in thinking skills and social behaviors. Alzheimer's disease is more common in people over 65 years old. The risk of developing Alzheimer's disease and other types of dementia increases with age,...

متن کامل

Effect of Long-term Exposure to Extremely Low-frequency Electromagnetic Fields on β-amyloid Deposition and Microglia Cells in an Alzheimer Model in Rats

Background: Recently, researchers have considered extremely low-frequency electromagnetic fields (ELF-EMFs), as one of the non-invasive therapies, in the treatment of many severe neurological disorders, including Alzheimer Disease (AD). AD is a progressive neurodegenerative disease characterized by the deposition of amyloid plaques in the brain. However, the increase in microglial cells increas...

متن کامل

Copper Status in Alzheimer's Disease and Other Neurodegenerative Disorders 2013

1 Department of Neuroscience, AFaR-Ospedale “San Giovanni Calibita” Fatebenefratelli, Isola Tiberina, 00186 Rome, Italy 2 Neurodegeneration Laboratory, IRCCS San Raffaele Pisana, 00166 Rome, Italy 3 Department of Neurology, University Hospital Utrecht, 3584 CX Utrecht, The Netherlands 4Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 4810...

متن کامل

The genetic causes of neurodegenerative diseases.

With the application of molecular genetics, we are now beginning to understand the etiology and the early stages of pathogenesis of the major neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Pick's disease and Progressive Supranuclear Palsy. Surprisingly, these studies are showing that these diseases share pathogenic mechanisms which involve tau or synuclein aggre...

متن کامل

Effect of Fennel Extract on the Improvement of Memory Disorders in Beta Amyloid Alzheimer Model of Male Wistar Rats

Introduction: Alzheimer's disease is the most common neurodegenerative disorder. Due to the neurodegenerative effect of fennel (Foeniculum vulgare) this study aimed at investigating the effect of this plant on the improvement of learning and memory in rat models of Alzheimer's disease. Material & Methods: The male Wistar rats were assigned into six groups, namely the control group (no i...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 2011  شماره 

صفحات  -

تاریخ انتشار 2011